Lipocalin 2 receptors: facts, fictions, and myths
نویسندگان
چکیده
The human 25-kDa Lipocalin 2 (LCN2) was first identified and purified as a protein that in part is associated with gelatinase from neutrophils. This shows high degree of sequence similarity the deduced sequences rat α -microglobulin-related mouse 24p3. Based on its typical lipocalin fold, which consists an eight-stranded, anti-parallel, symmetrical β-barrel fold structure it initially thought LCN2 circulating functioning transporter small lipophilic molecules. However, studies Lcn2 null mice have shown has bacteriostatic properties plays key role innate immunity by sequestering bacterial iron siderophores. Numerous reports further involved control cell differentiation, energy expenditure, death, chemotaxis, migration, many other biological processes. In addition, important roles for health disease been multiple molecular pathways required regulation expression identified. Nevertheless, although six putative receptors proposed, there fundamental lack understanding how these cell-surface transmit amplify to cell. present review we summarize current knowledge discuss inconsistencies, misinterpretations false assumptions potential receptors.
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Facts and fictions
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2023
ISSN: ['1664-3224']
DOI: https://doi.org/10.3389/fimmu.2023.1229885